Laboratory arc furnace features interchangeable hearths

Laboratory arc furnace using rapidly interchangeable hearths gains considerable versatility in casting so that buttons or special shaped castings can be produced. It features a sight glass for observation

Sintering characteristics and properties of PuS and PuP are determined

Report on the preparation of plutonium monosulphide and plutonium monophosphide includes a description of the sintering characteristics and properties of these high-temperature compounds. data on weight loss, microstructure, density, melting point, thermal expansion, microhardness, Seebeck coefficient, and thermal diffusion are included

Kinetics of the reaction of nitric oxide with hydrogen

Mixtures of NO and H2 diluted in argon or krypton were heated by incident shock waves, and the infrared emission from the fundamental vibration-rotation band of NO at 5.3 microns was used to monitor the time-varying NO concentration. The reaction kinetics were studied in the temperature range 2400-4500 K using a shock-tube technique. The decomposition of nitric oxide behind the shock was found to be modeled well by a fifteen-reaction system. A principle result of the study was the determination of the rate constant for the reaction H + NO yields N + OH, which may be the rate-limiting step for NO removal in some combustion systems. Experimental values of k sub 1 were obtained for each test through comparisons of measured and numerically predicted NO profiles

Mitigating Alcohol Health Hazards Through Health Warning Labels and Public Education

Alcohol is the most commonly abused drug in America today; yet, there has been no serious national effort to warn or educate the American public about the non-obvious dangers of its consumption. Courts refuse to impose liability on alcoholic beverage manufacturers for injuries arising out of their failure to warn consumers of the dangers of alcoholic beverages. They reason that the risks of alcohol consumption are widely known among the consuming public. Yet, Americans are actually less aware of the dangers of alcohol consumption than of the risks of smoking. This problem may be solved in several ways. A first step would be to impose tort liability on manufacturers for harm to consumers due to failure to warn. A second step would involve federal regulatory action. Congress could institute a national, uniform public education and labeling program which would make specific health hazard messages available to all alcoholic beverage consumers. Two bills requiring such health hazard warnings on the labels of all alcoholic beverage containers were recently introduced in Congress. If enacted, they could provide consumers with the same basic information on alcohol that is available on most other legal drugs, as well as identify specific dangers associated with alcohol. By expanding the proposed legislation to include a public education program, Congress could decisively promote public awareness

\u3cb\u3ePersonal Reflection:\u3c/b\u3e Rough Seas to Calmer Waters: The Journey of an Early Career Academic

As an early career academic I have had the opportunity to reflect on my early experiences in academia. This paper is a reflection on my journey through rough seas to calmer waters. This paper describes an uneasy voyage of experience, from confident practitioner to uncertain academic. Helping to steer me through uncharted waters on the high seas of academia was the Graduate Certificate in Education (University Teaching). This experience was instrumental in my development as an academic. Key to this personal reflection is discovery, action and reflection

Mitigating Alcohol Health Hazards Through Health Warning Labels and Public Education

Alcohol is the most commonly abused drug in America today; yet, there has been no serious national effort to warn or educate the American public about the non-obvious dangers of its consumption. Courts refuse to impose liability on alcoholic beverage manufacturers for injuries arising out of their failure to warn consumers of the dangers of alcoholic beverages. They reason that the risks of alcohol consumption are widely known among the consuming public. Yet, Americans are actually less aware of the dangers of alcohol consumption than of the risks of smoking. This problem may be solved in several ways. A first step would be to impose tort liability on manufacturers for harm to consumers due to failure to warn. A second step would involve federal regulatory action. Congress could institute a national, uniform public education and labeling program which would make specific health hazard messages available to all alcoholic beverage consumers. Two bills requiring such health hazard warnings on the labels of all alcoholic beverage containers were recently introduced in Congress. If enacted, they could provide consumers with the same basic information on alcohol that is available on most other legal drugs, as well as identify specific dangers associated with alcohol. By expanding the proposed legislation to include a public education program, Congress could decisively promote public awareness

Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease.

Autosomal dominant polycystic kidney disease (ADPKD) is a widespread genetic disease that leads to renal failure in the majority of patients. The very first pharmacological treatment, tolvaptan, received Food and Drug Administration approval in 2018 after previous approval in Europe and other countries. However, tolvaptan is moderately effective and may negatively impact a patient's quality of life due to potentially significant side effects. Additional and improved therapies are still urgently needed, and several clinical trials are underway, which are discussed in the companion paper Müller and Benzing (Management of autosomal-dominant polycystic kidney disease-state-of-the-art) Clin Kidney J 2018; 11: i2-i13. Here, we discuss new therapeutic avenues that are currently being investigated at the preclinical stage. We focus on mammalian target of rapamycin and dual kinase inhibitors, compounds that target inflammation and histone deacetylases, RNA-targeted therapeutic strategies, glucosylceramide synthase inhibitors, compounds that affect the metabolism of renal cysts and dietary restriction. We discuss tissue targeting to renal cysts of small molecules via the folate receptor, and of monoclonal antibodies via the polymeric immunoglobulin receptor. A general problem with potential pharmacological approaches is that the many molecular targets that have been implicated in ADPKD are all widely expressed and carry out important functions in many organs and tissues. Because ADPKD is a slowly progressing, chronic disease, it is likely that any therapy will have to continue over years and decades. Therefore, systemically distributed drugs are likely to lead to potentially prohibitive extra-renal side effects during extended treatment. Tissue targeting to renal cysts of such drugs is one potential way around this problem. The use of dietary, instead of pharmacological, interventions is another